Welcome to the Alliance Protein Laboratories, Inc. web site! APL
offers contract research services in the areas of protein
biophysical characterization, protein aggregation, protein purification, and protein stabilization.
If you are looking for analytical ultracentrifugation (AUC),
circular dichroism, light scattering,
DSC, fluorescence, or native gel analysis of your biotech product, or help with your protein
aggregation problems, you have found the right
place! We have now done such analysis on literally hundreds of products, giving our scientists unparalleled
APL has upgraded our DSC capabilities
with the installation of a new automated capillary DSC from TA Instruments.
This instrument has even higher sensitivity than the GE/Microcal capillary
demonstrated a new
sedimentation equilibrium protocol that allows us to measure the
weight-average mass of highly concentrated protein formulations (up to ~200
mg/mL) to characterize the weak attractive or repulsive interactions between
the protein molecules (colloidal stability), and which requires only ~20
microliters per sample (per concentration).
We've been doing this for over 16 years and have completed over 1,700
projects for 250+ clients
At APL the experiments and data interpretation are done by recognized
experts with extensive experience in these biophysical techniques, not by a technician, and
on our own equipment, not in a university lab.
We've already worked with over 250 biotherapeutics and vaccines, including most of the major biotech products (cytokines, interferons,
growth factors, scores of monoclonal antibodies, vaccines, viral vectors for
gene therapy ...), and we have already been working with biosimilars for over
10 years. That
collective experience helps us interpret our data, and can help get
your product to the patients who need it!
The Frequently Asked
Questions (FAQs) page covers topics such as fees, turn-around, confidentiality, academic
collaborations, and other aspects of doing business with us. The Lab
Tour will tell you more about our facilities and location. Before you
visit our lab check Driving Directions.
also visit our Other Related Services page to find links to other quality contract research labs
founded by former Amgen colleagues.
Alliance Protein Laboratories is a contract research and consulting firm
specializing in biophysical analysis. We offer:
A.P.L. is a spin-off from the Protein Chemistry department at Amgen. It was
founded in 1998 by Drs. Tsutomu Arakawa and John Philo. Our laboratory is
located in the heart of the biotechnology cluster in San Diego, CA. Our clients include
over 250 companies in North America, Europe, Asia, and Australia as well as
major universities and non-profit institutes.
Alliance Protein Laboratories, Inc.
6042 Cornerstone Court West, Suite A
San Diego, CA 92121
(note: we cannot receive shipments marked for 7-8 am
delivery or Saturday delivery. If your sample shipment includes temperature monitors, please
provide packaging and shipping documentation for their return.)
You can use this Contact Form to send
us an e-mail, or use the convention firstname.lastname @ our domain,