Alliance Protein Laboratories specializes in biophysical and biochemical characterization of proteins, nucleic acids, and other macromolecular assemblies (viral vectors for gene therapy, protein-polymer conjugates, etc.)  We offer characterization services not available from any other U.S. contract lab, including analytical ultracentrifugation (AUC). Our scientists pioneered the application of a number of biophysical techniques in the biotechnology industry.

A.P.L. offers various techniques to measure protein folding (secondary/tertiary structure), protein stability, protein conformation, the oligomeric state of the native protein (quaternary structure), and protein aggregation. 

A.P.L. now offers characterization of oligomeric state and aggregation by two different light scattering techniques, dynamic light scattering and on-line classical light scattering used with size-exclusion chromatography.

A.P.L. can also quantify protein-protein or protein-ligand interactions, e.g. for functional assessment of antibody-antigen or hormone-receptor pairs. 

A.P.L. can now supply FTIR and fluorescence characterization through collaboration with Integrity Biosolution, a protein formulation and delivery firm recently spun off from Amgen.

The techniques offered and some of their uses are listed on the Methods Summary page. Several general applications and the benefits of detailed characterization are discussed on the Example Applications page. More details and specific examples for some of the techniques are discussed on their individual pages:

Key Benefits from Using A.P.L. for Characterization Services